| Pair Name | GingerenoneA, Dexamethasone | ||
| Phytochemical Name | GingerenoneA (PubChem CID: / ) | ||
| Anticancer drug Name | Dexamethasone (PubChem CID: 5743 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | GingerenoneA, Dexamethasone | |||
| Disease Info | [ICD-11: 2B33.3] | Acute lymphoblastic leukemia | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | CDKN1A | hsa1026 |
| Down-regulation | Expression | FASN | hsa2194 | |
| Up-regulation | Expression | MDM2 | hsa4193 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| In Vitro Model | CCRF-CEM | Childhood T acute lymphoblastic leukemia | Homo sapiens (Human) | CVCL_0207 |
| NALM-6 | Adult B acute lymphoblastic leukemia | Homo sapiens (Human) | CVCL_0092 | |
| RN95 | B‐ALL subline derived from a 12‐year‐old Iranian girl with relapsed ALL | Homo sapiens (Human) | N.A. | |
| Result | Our findings may provide novel strategies for therapeutic intervention to ameliorate pALL outcomes. | |||
| No. | Title | Href |
|---|---|---|
| 1 | GingerenoneA overcomes dexamethasone resistance by activating apoptosis and inhibiting cell proliferation in pediatric T-ALL cells. Cancer Sci. 2023 Oct;114(10):3984-3995. doi: 10.1111/cas.15936 | Click |
